What is MTFHR enzyme?

MTHFR stands for methyl-tetrahydrofolate reductase, an enzyme that is responsible for the process of methylation in every cell in your body. This enzyme plays a role in processing toxic homocysteine into methionine. MTFHR is important for activating Folate acid also knows as B9. Specifically, this enzyme converts the inactive form of B9 to the active form so it can be used by the cells. This reaction is required for the multistep process that converts the amino acid homocysteine to another amino acid, methionine. The body needs methionine to make essential proteins and compounds. This error of transcription can lead to many neurological, cardiovascular and serious conditions. There are many different mutations of genetic defects can passed on by one parent or both parents.


Possible Signs and Symptoms associated with MTFHR defect

Neurological effects of MTFHR

  • Hyperactivity
  • Sleep disorder
  • High anxiety and panic disorders
  • Depression
  • OCD
  • Autism
  • Memory loss
  • Alzheimer’s
  • Parkinson’s
  • Decrease in essential neurotransmitters that control our mood such as Dopamine, serotonin, SAMe, epinephrine and norepinephrine

Physiological effects of MTFHR

  • Weight gain
  • Muscle pain
  • Fibromyalgia
  • Headaches
  • Brain fog
  • Hand tremor
  • Chronic fatigue
  • Ulcers

 Cardiovascular effects of MTFHR

  • High blood pressure
  • Thrombosis
  • Coronary heart disease
  • Pure circulation

Developmental effects of MTFHR

  • Slow growth
  • Underachievement at school
  • Difficulty learning
  • Reduced concentration

Immune effects of MTFHR

  • Seasonal allergies
  • Immune dysfunction
  • Recurrent cold and infections

Other including Erectile dysfunction, IBS, Fatty liver, cancer, reproductive issues and miscarriages

This list of common signs and symptoms are continually changing based on the latest evidence. Gene mutation can be passed by mum or dad or any of them. There are different types of MFHR mutation so supplementing only with Folic acid can worsen the symptoms. 

Who can benefit from MTFHR testing?

It is very common to have a genetic polymorphism in the MTHFR gene, one in two people get affected. Restoring the levels of active form of B9 can have a detrimental effect on quality of life.

How to treat?

After working with 100′s of individuals with this defect, I’ve developed a protocol which may help a significant number of people. There are many recommendations for people who suffer from this genetic predisposition. However developing individualised protocols and receive guidance from an experienced professional is very important to overcome any adverse reaction which can make your situation worse. 

Base product for some of the genetic predispositions: Methyl Guard 

Please contact my clinic to make an appointment Vitalchi Wellness or click below 


To learn more about the common recommendations for supporting those with MTHFR mutations